GenuIN Biotech utilizes its self-developed ShGE™ gene silencing platform to construct a series of validated stable gene knockdown (Knockdown-Validated, KD) cell lines. shRNA (short hairpin RNA) specifically downregulates the mRNA expression of the target gene through the RNA interference mechanism, achieving its long-term silencing at the mRNA level. These are widely used in basic research and drug development.
We use shRNA lentivirus to stably integrate the interference sequence into the cell genome, thereby achieving long-term stable gene silencing effects. This method is particularly suitable for cell types with low traditional transfection efficiency or non-dividing cells.